Calcium Channel Modulator

Hypaconitine (Standard) is the analytical standard of Hypaconitine. This product is intended for research and analytical applications. Hypaconitine inhibits the KCNH2 current with an IC₅₀ of 8.1 nM, and exhibits cardiotoxicity. Hypaconitine inhibits TGF-β1-induced epithelial-mesenchymal transition (EMT) in A549 cell through the inhibition of NF-κB nuclear translocation. Hypaconitine acts as the neuromuscular blocker. Hypaconitine is orally active.

Sadopine is an allosteric modulator for dihydropyridine receptor ((-)Sadopine as positive allosteric modulator and (+)Sadopine as negative allosteric modulator). Sadopine interacts with dihydropyridine (DHP)-sensitive L-type calcium channels.

RyR2 stabilizer-1 (compound 12a) is a potent RyR2 stabilizer and SERCA2a activator with EC₅₀s of 2.7 μM for RyR2 and 383 nM for SERCA2. RyR2 stabilizer-1 inhibits Ca²⁺ leakage from the SR RyR2 while promoting SERCA2 to pump Ca²⁺ back to SR, which make RyR2 stabilizer-1 possible to prevent cardiac arrhythmias.

Calcium channel-modulator-1 is an orally active calcium channel modulator that blocks aortic contraction with an IC₅₀ of 0.8 μM. Calcium channel-modulator-1 can be used for the study of cardiovascular conditions.

Myomodulin is a neuropeptide present in molluscs, insects, and gastropods.